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Losartan: Dosing must be individualized. The usual starting dose of Losartan is 50mg once daily, with 25mg recommended for patients with intravascular volume depletion and patients with a history of hepatic impairment. Losartan can be administered once or twice daily at total daily doses of 25 to 100mg.
Amlodipine: The usual initial antihypertensive oral dose of Amlodipine is 5mg once daily with a maximum dose of 10mg once daily.
Small, fragile, or elderly patients, or patients with hepatic insufficiency may be started on 2.5mg once daily and this dose may be used when adding Amlodipine to other hypertensive therapy.
Adjust dosage according to patient's need. In general, titration should proceed over 7 to 14 days so that the physician can fully assess the patient's response to each dose level.
The recommended dose for chronic stable or vasospastic angina is 5-10mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency. Most patients will require 10mg for adequate effect.
The recommended dose range for patients with coronary artery disease is 5-10mg once daily.
Hydrochlorothiazide: Hydrochlorothiazide is effective in doses of 12.5 to 50mg once daily and can be given at doses of 12.5 to 25mg.
